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CEO of Arkeon reflects on 'air protein' venture: 'Time simply ran out on us'

In 2021, protein production company Arkeon began using gas fermentation. However, by 2025, the company had to file for bankruptcy. The question remains, what led to this downfall?

Arkeon's CEO discusses the demise of their 'air protein' company: 'Simply, we ran out of time'
Arkeon's CEO discusses the demise of their 'air protein' company: 'Simply, we ran out of time'

CEO of Arkeon reflects on 'air protein' venture: 'Time simply ran out on us'

In a recent turn of events, Vienna-based startup Arkeon, which focused on producing proteins through gas fermentation, has filed for insolvency four years after its inception. The company's demise, according to reports, was primarily due to investment challenges and funding instability.

Initially, Arkeon aimed to revolutionise the protein production industry by creating protein from air using gas fermentation of wild-type microbes. The goal was to produce amino acid mixtures as potential replacements for whole plant proteins, addressing common issues such as off-flavours and undesirable functionalities in plant-based protein products.

However, the broader challenges facing gas fermentation startups are numerous. Persuading partners, investors, and customers of the market demand for novel proteins, securing affordable and truly green sources of inputs like gases, and overcoming the high capital expenditures needed for commercial-scale production facilities are just a few examples.

Despite these hurdles, experts believe the technology itself is commercially viable and scalable. Investors and founders in the sector note that gas fermentation can match existing amino acid production processes on price at scale.

Arkeon's experience offers valuable lessons for the synthetic biology and gas fermentation industry. One key takeaway is the importance of investor confidence. The sudden withdrawal of a single investor can create widespread panic and jeopardize entire funding rounds. Startups should diversify their investor base and maintain strong, transparent communications to mitigate such risks.

Another lesson is the need for long-term financial planning and diversified funding. Gas fermentation and synthetic biology ventures often require large upfront capital for scale-up and production facilities, exposing them to "valley of death" risks where technology maturity and commercial readiness must align with funding availability.

Market validation and customer adoption are also crucial. Demonstrating a clear, compelling market need and differentiating product advantages are essential to attract and retain investor and customer interest.

Operational flexibility is vital when facing uncertain financial conditions. Cost management and adaptive business strategies are necessary to extend runway and explore alternative funding or exit strategies.

Lastly, while the scientific approach may be sound and scalable, successful commercialization hinges on effective business execution, market timing, and reliable financial backing.

Looking ahead, gas fermentation technology can be adapted over time as green hydrogen becomes more available and affordable. Using saltwater broths with hydrogen and CO2 as inputs is less prone to contamination, allowing for extended production campaigns and potentially eliminating the need for sterilization.

In summary, Arkeon's insolvency reflects the broader challenges in commercialising deep tech synthetic biology innovations. The incident underscores the need for robust financial planning, diversified funding, and clear market pathways to ensure sustainable growth in this cutting-edge field.

The technology of gas fermentation, as demonstrated by Arkeon, has potential to match the cost of existing amino acid production processes at scale. However, startups in this sector face various challenges, such as securing investment, ensuring green sources of inputs, and overcoming high capital expenditures for commercial-scale production.

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